| Description | NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent. |
| In vivo | NSI-189 在脑卒中后脑部重塑活动中显示出积极作用。进一步的体外研究探讨了这一重塑过程，证明了氧糖剥夺及再灌注（OGD/R）引起的典型细胞死亡过程，而NSI-189的处理显著逆转了OGD/R引起的海马细胞死亡，并增加了Ki67和MAP2的表达，同时上调了如BDNF和SCF等神经生成因子。这些发现支持使用口服NSI-189作为治疗剂，在卒中后最初6个月内加速和增强整体功能改善，超出最初的6小时治疗窗口。 |
| Synonyms | NSI189 Phosphate, NSI 189 Phosphate, NSI-189磷酸盐 |
| molecular weight | 464.5 |
| Molecular formula | C22H33N4O5P |
| CAS | 1270138-41-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/ml (139.94 mM) |
| References | 1. Tajiri N , Quach D M , Kaneko Y , et al. NSI‐189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats[J]. Journal of Cellular Physiology, 2017. 2. Karl K Johe, Gary Kay, Santosh Kumar, et al.NSI-189 phosphate, a novel neurogenic compound, selectively benefits moderately depressed patients: A post-hoc analysis of a phase 2 study of major depressive disorder.Ann Clin Psychiatry. 2020 Aug;32(3):182-196. |