| Description | NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma TT cells. The compound is utilized in research investigating acute toxicity in normal tissues due to radiation and chemotherapy [1] [2]. |
| molecular weight | 317.38 |
| Molecular formula | C20H19N3O |
| CAS | 5358-76-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |