PeptideDB

NSC-741909

CAS No.: 92407-91-5

NSC-741909 is an anticancer agent that acts by suppressing the growth of several cell lines.
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Description NSC-741909 is an anticancer agent that acts by suppressing the growth of several cell lines.
molecular weight 271.74
Molecular formula C16H14ClNO
CAS 92407-91-5
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Guo W, Wu S, Wang L, Wei X, Liu X, Wang J, Lu Z, Hollingshead M, Fang B. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One. 2011;6(12):e28487. doi: 10.1371/journal.pone.0028487. Epub 2011 Dec 12. PubMed PMID: 22174819; PubMed Central PMCID: PMC3236185. 2. Guo W, Wei X, Wu S, Wang L, Peng H, Wang J, Fang B. Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. Eur J Pharmacol. 2010 Dec 15;649(1-3):51-8. doi: 10.1016/j.ejphar.2010.08.057. Epub 2010 Sep 18. PubMed PMID: 20854805; PubMed Central PMCID: PMC2967662. 3. Wei X, Guo W, Wu S, Wang L, Huang P, Liu J, Fang B. Oxidative stress in NSC-741909-induced apoptosis of cancer cells. J Transl Med. 2010 Apr 16;8:37. doi: 10.1186/1479-5876-8-37. PubMed PMID: 20398386; PubMed Central PMCID: PMC2873373. 4. Wei X, Guo W, Wu S, Wang L, Lu Y, Xu B, Liu J, Fang B. Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells. J Biol Chem. 2009 Jun 19;284(25):16948-55. doi: 10.1074/jbc.M109.010256. Epub 2009 May 4. PubMed PMID: 19414586; PubMed Central PMCID: PMC2719332.