| Description | NP603 is a cell-permeable inhibitor of FGFR1, PDGFRβ, and VEGFR2 that binds to the ATP pocket. It also is a very weak EGFR inhibitor. |
| Synonyms | NP 603, NP-603 |
| molecular weight | 446.49 |
| Molecular formula | C26H26N2O5 |
| CAS | 949164-80-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lin N, Chen S, Pan W, Xu L, Hu K, Xu R. NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats. Am J Physiol Cell Physiol. 2011 Aug;301(2):C469-77. doi: 10.1152/ajpcell.00452.2010. Epub 2011 May 4. PubMed PMID: 21543745. 2. Kammasud N, Boonyarat C, Tsunoda S, Sakurai H, Saiki I, Grierson DS, Vajragupta O. Novel inhibitor for fibroblast growth factor receptor tyrosine kinase. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4812-8. Epub 2007 Jun 26. PubMed PMID: 17618113. |