| Description | NP-G2-044 is an orally active fascin inhibitor, with an IC50 of ~2 μM. It blocks tumor metastasis and increases antitumor immune response. |
| In vitro | NP-G2-044以IC50约10 μM抑制MDA-MB-231肿瘤细胞迁移。它通过减少丝状足的形成导致减少板状足的形成[1]。 |
| In vivo | NP-G2-044（100 mg/kg；i.p.；每日一次，连续18天）在小鼠模型中抑制乳腺肿瘤的转移[1]。 |
| Target activity | Fascin:2 μM |
| molecular weight | 399.37 |
| Molecular formula | C21H16F3N3O2 |
| CAS | 1807454-59-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (250.39 mM), Sonication is recommended. |
| References | 1. Han S, et al. Improving fascin inhibitors to block tumor cell migration and metastasis. Mol Oncol. 2016;10(7):966-980. 2. Vincent Chung, et al. Abstract C053: NP-G2-044, a novel fascin inhibitor, blocks tumor metastasis and increases antitumor immune response. |