| Description | Nortriptyline is an antidepressant compound that enhances corticosteroid sensitivity of blood T-cells in patients with chronic obstructive pulmonary disease (COPD) and may be used for smoking cessation. |
| In vitro | 在 人 TCCSUP 和小鼠 MBT-2 膀胱癌细胞中，Nortriptyline （6.25 μM、12.5 μM、25 μM、50 μM和100 μM；处理时间为 24、48 或 72 小时）对 TCCSUP 和 MBT-2 细胞展现出了细胞毒性效应[3]。 |
| In vivo | 在接种了 MBT-2 细胞的成年雄性 C3H/HeN 小鼠（体重 25-30 克，年龄 2-3 个月）中，Nortriptyline（10 或 20 mg/kg；腹腔注射；每日 1 次；持续 3 周）能够抑制接种了 MBT-2 细胞的小鼠体内的肿瘤生长[3]。 |
| molecular weight | 263.38 |
| Molecular formula | C19H21N |
| CAS | 72-69-5 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); March 23, 2017. 2. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. 3. Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20. |