| Description | Nortopixantrone HCl (BBR 3438) is a novel 9-azacyclonopyrazole that shows antitumor activity in a human prostate cancer model. |
| Synonyms | BBR3438, Nortopixantrone hydrochloride, BBR-3438 |
| molecular weight | 453.36 |
| Molecular formula | C20H26Cl2N6O2 |
| CAS | 438244-41-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.53 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Cao, Y., Luo, C., Yang, P. et al. Indazole scaffold: a generalist for marketed and clinical drugs. Med Chem Res 30, 501–518 (2021). 2. Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jan-Feb;25(1):53-76. PubMed PMID: 12690708. 3. Supino R, Polizzi D, Pavesi R, Pratesi G, Guano F, Capranico G, Palumbo M, Sissi C, Richter S, Beggiolin G, Menta E, Pezzoni G, Spinelli S, Torriani D, Carenini N, Dal Bo L, Facchinetti F, Tortoreto M, Zunino F. A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts. Oncology. 2001;61(3):234-42. PubMed PMID: 11574780. |