| Description | Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy. |
| In vivo | Nonabine是一种与cannabinoids结构相关的chromenol化合物，在临床试验中显示出了抗呕吐效能。Nonabine还产生了镇静的临床效果，但其EEG轮廓与报道中cannabinoids引起的相似。与cannabinoids不同，Nonabine没有引起情绪或感知的变化，表明在抗呕吐剂量下Nonabine缺乏社会滥用潜力。[1] |
| molecular weight | 379.54 |
| Molecular formula | C25H33NO2 |
| CAS | 16985-03-8 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (144.91 mM) |
| References | 1. McClelland GR, et al. Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects. Psychopharmacology (Berl). 1985;85(3):306-8. 2. Staquet M, et al. Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting. J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):60S-63S. 3. Archer CB, et al. Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine. Br Med J (Clin Res Ed). 1983 Jan 29;286(6362):350-1. |