| Description | NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM). |
| Target activity | NMDA:Ki of 0.85 nM |
| molecular weight | 375.87 |
| Molecular formula | C20H23ClFN3O |
| CAS | 700878-19-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 12 mg/mL (31.93 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. McCauley JA, et al. NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. |