| Description | Nitromifene is the estrogen receptor antagonist. |
| In vitro | Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase. Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls, at 0.5 μM and 1.0 μM concentrations. Nitromifene is clearly more effective than other metabolites, at higher concentrations. Specifically, bound estradiol is displaced from intact MCF 7 cells by Nitromifene . |
| Synonyms | CI628 |
| molecular weight | 444.52 |
| Molecular formula | C27H28N2O4 |
| CAS | 10448-84-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Ruenitz PC, et al. Characterization of MCF 7 breast cancer cell growth inhibition by the antiestrogen nitromifene (CI 628) and selected metabolites. J Steroid Biochem. 1989 Sep;33(3):365-9. |