| Description | Niridazole (Ambilhar) is an antiparasitic compound belonging to nitroimidazoles. Niridazole is primarily used to treat schistosomiasis, which kills the parasite by interfering with its metabolism. Niridazole rapidly concentrates in the parasite, inhibits egg and sperm production, and inhibits phosphofructokinase activity. |
| In vitro | Niridazole 的最小抑菌浓度范围从0.0037到1.0 microgram/ml [1]。 |
| In vivo | Niridazole，一种人用驱虫化合物，被证明是一种效果持久的强效迟发性超敏反应抑制剂。化合物在治疗蠕虫感染所用剂量远低于对抑制小鼠体内Schistosoma mansoni卵周围肉芽肿形成达32天，以及抑制之前用卵敏感化的小鼠足肿胀的迟发性反应。在小鼠跨H-2区域的皮肤异体移植中，明显延长了移植皮肤的存活时间。[2] |
| Synonyms | BA32644, BA-32644, Ambilhar, BA 32644 |
| molecular weight | 214.2 |
| Molecular formula | C6H6N4O3S |
| CAS | 61-57-4 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/mL, Sonication is recommended. |
| References | 1. Hof H, et al. Comparative in vitro activities of niridazole and metronidazole against anaerobic and microaerophilic bacteria. Antimicrob Agents Chemother. 1982;22(2):332-333. 2. Mahmoud AA, Mandel A, Warren K, Webster LT Jr. Niridazole. II. A potent long-acting suppressant of cellular hypersensitivity. J Immunol. 1975;114(1 Pt 2):279-283. 3. Wade WG, Addy M. Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. J Appl Bacteriol. 1987 Nov;63(5):455-7. PubMed PMID: 3440767. 4. Ma Z, Si BX, Liu YL, Huang LS. [Synthesis of acylates of niridazole and its analogs as schistosomicides]. Yao Xue Xue Bao. 1989;24(6):476-80. Chinese. PubMed PMID: 2609988. |