| Description | NiCur blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur is a potent and selective inhibitor of CBP histone acetyltransferase (HAT) with an IC 50 value of 0.35 μΜ. NiCur can be used to perform mechanistic studies without affecting target proteins expression [1]. |
| In vitro | NiCur (0.5~1 μM; U2OS cells) reduces the Dox-induced p53K382ac, p53S15p, and p53 levels in a dose-dependent manner [1]. NiCur (1.5 μM) reduces the level of H3K27ac. NiCur (1.5 μM; U2OS cells) restores cellular proliferation. NiCur (Intestinal epithelial cells) down-regulates Dox-mediated p53 activation without affecting the levels of H2A.X S139p. NiCur can modulate the gene regulatory switch for reprogramming chromatin landscape. NiCur blocks CBP HAT activity [1]. Western Blot Analysis [1] Cell Line: U2OS cells Concentration: 0.5~1 μM Incubation Time: Result: Reduced the Dox-induced p53K382ac, p53S15p, and p53 levels in a dose-dependent manner. |
| molecular weight | 324.38 |
| Molecular formula | C22H16N2O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |