| Description | Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL. |
| In vitro | methyleugenol 自然存在于多种香料和草本植物中，包括罗勒及其精油。高剂量下，间苯三烯甲醚通过生物活化成为1'-硫酸氧化间苯三烯甲醚，与DNA形成加合物，从而在啮齿动物中诱发肝致癌性。【方法与结果】本研究探讨了Nevadensin对硫酸转移酶(SULT)-介导的间苯三烯甲醚生物活化的抑制作用是否能够反映为DNA加合物形成的减少以及在8周大鼠研究中减少肝癌早期标志的体现。间苯三烯甲醚与Nevadensin的口服共同暴露显著抑制了肝脏间苯三烯甲醚DNA加合物的形成，并抑制了肝细胞变异灶的诱导，这是肿瘤生成开始的指标。【结论】这些结果表明，与使用纯间苯三烯甲醚的实验相比，当间苯三烯甲醚在包含如Nevadensin这类SULT抑制剂的基质中投与时，啮齿动物生物测定中的肿瘤形成可能会减少。 |
| Target activity | CE2 (human):132.8 μM (IC50), CE1 (human):2.64 μM (IC50) |
| Synonyms | Pedunculin, 石吊兰素, 5,7-二羟基-6,8,4'-三甲氧基黄酮 |
| molecular weight | 344.32 |
| Molecular formula | C18H16O7 |
| CAS | 10176-66-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 14.71 mg/mL (42.72 mM), Sonication is recommended. |
| References | 1. The natural basil flavonoid nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. Food Chem Toxicol. 2014 Dec;74:28-34. 2. Antimycobacterial and antioxidant flavones from Limnophila geoffrayi. Arch Pharm Res. 2003 Oct;26(10):816-20. |