| Description | NeuroSensor 521 is a fluorescent turn-on sensor. It acts by binding catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate. |
| Synonyms | NeuroSensor521, NeuroSensor-521 |
| molecular weight | 351.4 |
| Molecular formula | C21H21NO4 |
| CAS | 1428730-05-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hettie KS, Glass TE. Coumarin-3-aldehyde as a scaffold for the design of tunable PET-modulated fluorescent sensors for neurotransmitters. Chemistry. 2014 Dec 22;20(52):17488-99. doi: 10.1002/chem.201403128. Epub 2014 Oct 24. PubMed PMID: 25346467. 2. Hettie KS, Liu X, Gillis KD, Glass TE. Selective catecholamine recognition with NeuroSensor 521: a fluorescent sensor for the visualization of norepinephrine in fixed and live cells. ACS Chem Neurosci. 2013 Jun 19;4(6):918-23. doi: 10.1021/cn300227m. Epub 2013 Mar 25. PubMed PMID: 23527575; PubMed Central PMCID: PMC3708293. |