| Description | NEU-1045 is a T. brucei proliferation inhibitor, and is a promising lead with cross-pathogen activity. NEU-1045 inhibited T. brucei, T. cruzi, and L. major proliferation with good potency (T. brucei EC50 = 0.37 μM; T. cruzi EC50 = 2.8 μM; L. major EC50 = 1.2 μM). |
| Synonyms | NEU 1045, NEU1045 |
| molecular weight | 569.65 |
| Molecular formula | C32H28FN3O4S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites William DevineSarah M. ThomasJessey ErathKelly A. BachovchinPatricia J. LeeSusan E. LeedAna RodriguezRichard J. SciottiKojo Mensa-Wilmotand Michael P. Pollastri Publication Date (Web): February 5, 2017 (Letter) doi: 10.1021/acsmedchemlett.7b00011 |