| Description | Netropsin is a basic polypeptide isolated from Streptomyces netropsis with antibiotic and antiviral activity. It is strong, specific binding to A-T areas of DNA is useful to genetics research. Netropsin is active against Gram-negative bacteria and Gram-positive bacteria. |
| Synonyms | Congocidin, Antibiotic T 1384, Antibiotic 1142, Antibiotic T-1384, Sinanomycin, Antibiotic T1384 |
| molecular weight | 430.46 |
| Molecular formula | C18H26N10O3 |
| CAS | 1438-30-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: Insoluble DMSO: Soluble |
| References | 1. Chung JH, Bhat A, Kim CJ, Yong D, Ryu CM. Combination therapy with polymyxin B and netropsin against clinical isolates of multidrug-resistant Acinetobacter baumannii. Sci Rep. 2016 Jun 16;6:28168. doi: 10.1038/srep28168. PubMed PMID: 27306928; PubMed Central PMCID: PMC4910107. 2. Andronova VL, Grokhovsky SL, Surovaya AN, Gursky GV, Galegov GA. Effect of dimeric netropsin analogue 15Lys-bis-Nt and acyclovir on the reproduction of herpes simplex virus type 1. The search for variants of herpes virus with drug resistance to 15Lys-bis-Nt and acyclovir. Dokl Biochem Biophys. 2015;460:42-6. doi: 10.1134/S1607672915010123. Epub 2015 Mar 13. PubMed PMID: 25772989. 3. Szerszenowicz J, Drozdowska D. Semi-automatic synthesis, antiproliferative activity and DNA-binding properties of new netropsin and bis-netropsin analogues. Molecules. 2014 Jul 31;19(8):11300-15. doi: 10.3390/molecules190811300. PubMed PMID: 25090119. 4. Ramos JP, Le VH, Lewis EA. Role of water in netropsin binding to an A(2)T(2) hairpin DNA site: osmotic stress experiments. J Phys Chem B. 2013 Dec 19;117(50):15958-65. doi: 10.1021/jp408077m. Epub 2013 Dec 5. PubMed PMID: 24274393. |