| Description | Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. |
| In vivo | Netarsudil (AR-13324; 0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes [1]. Netarsudil hydrochloride (0.04%) produces a statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits [2]. |
| Synonyms | AR-13324 (mesylate) |
| molecular weight | 645.74 |
| Molecular formula | C30H35N3O9S2 |
| CAS | 1422144-42-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (154.86 mM), Sonication is recommended. |
| References | 1. Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4. 2. Levy B, et al. Ocular hypotensive safety and systemic absorption of AR-13324 ophthalmic solution in normal volunteers. Am J Ophthalmol. 2015 May;159(5):980-5.e1. |