| Description | Nesosteine Lithium is a novel mucoregulatory that inhibits Herxheimer microconvulsions in guinea pigs and inhibits ovalbumin-induced histamine release from sensitized trachea.Nesosteine Lithium protects against ovalbumin-induced bronchospasm but is ineffective against histamine- and acetylcholine-induced bronchospasm. Nesosteine Lithium protected against ovalbumin-induced bronchospasm but not histamine- and acetylcholine-induced bronchospasm. |
| In vitro | Nesosteine (10(-5) M) inhibits ovalbumin-induced histamine release in the trachea of sensitized animals. In the same preparation, the drug is ineffective against the contractions induced by histamine or acetylcholine.[2] |
| In vivo | Nesosteine (5-50 mg/kg; guinea-pigs) is able to protect sensitized animals from ovalbumin-induced bronchospasm. On the other hand, the drug is ineffective against the bronchospasm induced by histamine and acetylcholine.[2] |
| Synonyms | Nesosteine Lithium(84233-61-4 Free baes) |
| molecular weight | 243.22 |
| Molecular formula | C11H10LiNO3S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 7.5 mg/mL (30.84 mM) |
| References | 1. Braga PC, et al. Rheological profile of nesosteine: a new mucoactive agent. Int J Clin Pharmacol Res. 1989;9(1):77-83. 2. Franchi-Micheli S, et al. Effects of nesosteine on Herxheimer microshock in guinea-pigs. Agents Actions. 1987;20(3-4):327-329. |