| Description | Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain. |
| In vitro | Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcαμRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcαμRI α± chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-Methoxyluteolin on the cell surface expression and the mRNA level of the FcαμRI α± chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively. |
| Synonyms | 6-Methoxyluteolin, 泽兰黄酮, 6-甲氧基藤黄菌素 |
| molecular weight | 316.26 |
| Molecular formula | C16H12O7 |
| CAS | 520-11-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (31.62 mM) |
| References | 1. 6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum suppresses histamine release and calcium influx via down-regulation of FcαµRI α± chain expression.J Microbiol Biotechnol. 2012 May;22(5):622-7. |