| Description | Aminomalonic acid is an amino endogenous metabolite that acts as a potent inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR and mouse pancreas in vitro (Leukemia 5178Y/AR: Ki= 0.0023 M, mouse pancreas: Ki= 0.0015 M). It has the potential to be used as a biomarker to distinguish between different stages of melanoma metastasis. |
| In vitro | 通过高效液相制备技术准备了TMYXP的各个分数。这些所得分数的心脏保护效果在H2O2氧化损伤的H9c2心肌细胞上进行了测试。活性成分通过高效液相色谱（HPLC）联用高分辨率质谱进行了分析。通过比较其MS离子和分子量与文献，假设鉴定了可能的活性化合物。十种TMYXP成分表现出显着的心肌保护活性，其中5种经研究显示出良好的剂量效应关系。它们的中等有效浓度（EC50）分别为11.66、17.44、13.10、7.332、15.15 μg/mL。总共分析并鉴定了11种潜在活性化合物，包括甘草酸、Glycycoumarin、Licoisoflavone、Ophiopogonin D'、Licoricon、Gancaonin L、Neoglycyrol、Emodin、Angeloylgomisin H、Angeloylgomisin Q和Glyasperin A。 |
| molecular weight | 366.36 |
| Molecular formula | C21H18O6 |
| CAS | 23013-84-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 3.66 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Screening of active compounds with myocardial protective effects from Tongmai Yangxin pillZhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Mar;44(2):145-53. |