| Description | Nemonoxacin (TG-873870) is an orally available non-fluorinated quinolone antibiotic with broad-spectrum antimicrobial activity against staphylococci, streptococci, and enterococci, as well as against Neisseria gonorrhoeae and Haemophilus influenzae.Nemonoxacin is used in the study of bacterial infections and community-acquired pneumonia. |
| In vitro | Nemonoxacin（0-5.51 µM；24小时）能够抑制在甲氧苯青霉素敏感金黄色葡萄球菌（MSSA）和甲氧苯青霉素耐药金黄色葡萄球菌（MRSA），其 MIC90 值分别为0.12 µg/mL和4 µg/mL[1]。 |
| In vivo | 在 CD-1 ICR小鼠（18-22克；小鼠全身感染模型）中，Nemonoxacin（1.6-4.0 mg/kg；口服；感染后 15 分钟和 6 小时）显示出对不同类型耐药金黄色葡萄球菌侵袭的抗菌活性[2]。 |
| Synonyms | TG-873870 |
| molecular weight | 371.43 |
| Molecular formula | C20H25N3O4 |
| CAS | 378746-64-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 1 mg/mL (2.69 mM), Sonication is recommended. |
| References | 1. Adam HJ, et al. In vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates. Antimicrob Agents Chemother. 2009 Nov;53(11):4915-20. 2. Li CR, et al. In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone. J Antimicrob Chemother. 2010 Nov;65(11):2411-5. 3. Lauderdale TL, et al. Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. Antimicrob Agents Chemother. 2010 Mar;54(3):1338-42. |