| Description | Neboglamine hydrochloride (CR-2249 hydrochloride) is an orally active positive modulator of NMDA receptors with neuroprotective activity, enhances cognition, and may be used in studies of schizophrenia and lupus erythematosus. |
| In vivo | 在雄性 Wistar 大鼠中，Neboglamine hydrochloride（20 mg/kg；皮下注射）能够增加脑区域的神经元活性，前额叶皮层（PFCX）从38.5增加到121.3，伏隔核（NAc）从14.5增加到69.1，侧隔核（LSN）从16.2增加到73.1，但对背外侧纹状体（DL-STR）没有影响[1]。 |
| Synonyms | XY 2401 hydrochloride, CR-2249 hydrochloride |
| molecular weight | 292.8 |
| Molecular formula | C13H25ClN2O3 |
| CAS | 2759182-59-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Riccardo Chiusaroli, et al. Antipsychotic-like effects of the N-methyl-D-aspartate receptor modulator neboglamine: an immunohistochemical and behavioural study in the rat. Pharmacol Res. 2010 May;61(5):430-6. |