| Description | NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding via an unexpected mechanism of inhibition. |
| Target activity | ATP citrate lyase (human):2.1 nM |
| molecular weight | 453.84 |
| Molecular formula | C20H14ClF2NO5S |
| CAS | 2375840-87-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 91 mg/mL (200.51 mM) |
| References | 1. Jia, Wei, Silvana, et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase[J]. Nature, 2019. 2. Granchi C.Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase[J].Trends Pharmacol Sci. 2019 Jun;40(6):364-366. |