| Description | NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM. |
| In vitro | 在Caco-2细胞系中，NCT-501展现出了优异的渗透性。[1] |
| In vivo | 在CD1小鼠中，NCT-501被良好吸收和分布，但迅速代谢和/或排泄。[1] |
| Target activity | ALDH1A1:40 nM |
| Synonyms | NCT501 |
| molecular weight | 416.52 |
| Molecular formula | C21H32N6O3 |
| CAS | 1802088-50-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (72 mM) Ethanol: 24 mg/mL (57.6 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Yang SM, et al. J Med Chem. 2015, 58(15), 5967-5978. |