| Description | NCGC00135472 (DRV1 (GPR32) agonist C2A) is a human Resolvin DI receptor DRV1 agonist with pro-catabolic properties that activates the human soluble protein D1 receptor DRV1/GPR32 receptor in beta-blocker and cAMP assays with EC50s of 0.37 uM and 0.05 uM, respectively.NCGC00135472 induces in cells overexpressing recombinant DRV1 rapid impedance changes that stimulate phagocytosis of serum-treated zymoglycans. |
| In vitro | 我们实施了小分子库的高通量筛选，识别出激活重组DRV1的化学型态，包括NCGC00135472 (C2A)。在100 nM至10 mM剂量范围内，NCGC00135472 剂量依赖性地引起CHO-DRV1中阻抗的快速变化。[1] |
| Target activity | cAMP:0.05 μM, β-arrestin:0.37 μM |
| Synonyms | NCGC 00135472, DRV1 (GPR32) agonist C2A, C2A, NCGC-00135472 |
| molecular weight | 364.35 |
| Molecular formula | C20H14F2N4O |
| CAS | 862811-76-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1.8 mg/mL (5.0 mM) |
| References | 1. Chiang N, et al. Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions. Cell Chem Biol. 2019 Feb 21;26(2):244-254.e4. |