| Description | NC182 is a topo II inhibitor that shows selective and potent topo II inhibition on the induction of topo II-dependent DNA fragmentation. |
| Synonyms | NC 182, NC-182 |
| molecular weight | 448.47 |
| Molecular formula | C24H24N4O5 |
| CAS | 106224-67-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Apostolova LG, Hwang KS, Kohannim O, Avila D, Elashoff D, Jack CR Jr, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer's disease. Neuroimage Clin. 2014 Jan 4;4:461-72. doi: 10.1016/j.nicl.2013.12.012. eCollection 2014. PubMed PMID: 24634832; PubMed Central PMCID: PMC3952354. 2. Moorthy NS, Pratheepa V, Ramos MJ, Vasconcelos V, Fernandes PA. Fused aryl-phenazines: scaffold for the development of bioactive molecules. Curr Drug Targets. 2014;15(7):681-8. Review. PubMed PMID: 24499398. 3. Tarui M, Doi M, Ishida T, Inoue M, Nakaike S, Kitamura K. DNA-binding characterization of a novel anti-tumour benzo[a]phenazine derivative NC-182: spectroscopic and viscometric studies. Biochem J. 1994 Nov 15;304 ( Pt 1):271-9. PubMed PMID: 7998945; PubMed Central PMCID: PMC1137482. |