| Description | NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers. |
| Synonyms | NC1300B, NC 1300 B |
| molecular weight | 313.42 |
| Molecular formula | C17H19N3OS |
| CAS | 104340-52-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lin H,et al. Reduction in renin release and renal vascular resistance by H(+)-K(+)-ATPase inhibition. Am J Physiol. 1997 Sep;273(3 Pt 2):F457-62. 2. McCabe RD,et al. Evidence of a K(+)-H(+)-ATPase in vascular smooth muscle cells. Am J Physiol. 1992 Jun;262(6 Pt 2):H1955-8. 3. Okabe S, et al. Effects of NC-1300-B, a new benzimidazole derivative, on hog gastric H+, K+-ATPase, gastric acid secretion and HCl.ethanol-induced gastric lesions in rats. Dig Dis Sci. 1988 Nov;33(11):1425-34. 4. Rhoden KJ,et al. H+-K+ ATPase inhibitors cause relaxation of guinea pig and human airway smooth muscle in vitro. J Pharmacol Exp Ther. 1996 Mar;276(3):897-903. |