| Description | NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding. |
| In vitro | NBD-556 N-phenyl-N′-(2,2,6,6-四甲基-哌啶-4-基)-草酰胺类似物是一类新型的人类免疫缺陷病毒类型1（HIV-1）入侵抑制剂，能阻塞gp120与CD4的相互作用。这种小分子NBD-556通过与gp120外部包膜糖蛋白结合来模拟CD4，适度抑制病毒进入表达CD4的目标细胞，并增强CCR5结合及病毒进入缺乏CD4表达的CCR5表达细胞。 |
| molecular weight | 337.84 |
| Molecular formula | C17H24ClN3O2 |
| CAS | 333353-44-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 0.1 mg/mL (insoluble) DMSO: 33.33 mg/mL (98.66 mM), Sonication is recommended. |
| References | 1. Narumi, Tetsuo et al. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5853-5858. 2. Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45(36):10973-10980. 3. Singh IP, Chauthe SK. Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibitors: 2004-2010. Expert Opin Ther Pat. 2011 Mar;21(3):399-416. 4. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339 |