| Description | Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enters the cell and binds to and activates specific nuclear androgen receptors in responsive tissue, including the prostate, seminal vesicles, scrotum, penis, larynx, hair follicles, muscle, and bone. |
| In vitro | 在体外分化过程中，使用的浓度下，合成类固醇nandrolone decanoate无法改变肌肉细胞的活力[2]。 |
| In vivo | 高剂量的nandrolone decanoate会导致血清葡萄糖水平下降，同时伴随着空腹时高血清胰岛素水平。nandrolone decanoate的长期给药可减少葡萄糖产生率和肝糖原含量，这可能导致空腹血糖降低[1]。体内研究显示，nandrolone decanoate的效果取决于被评估的肌肉、治疗时间、剂量以及是否与运动相结合。这些因素能够增加肌肉质量、细胞周期的变化、骨矿物质密度、骨骼生长，并且ARs对这些效果有影响[2]。 |
| Cell experiments | Cell viability is assessed one, three and five days after incubation with nandrolone decanoate at the final concentrations of 5, 10, 25 and 50 µM or the drug vehicle (1.5:1-benzyl alcohol/peanut oil), added in different amounts according to the anabolic concentrations (vehicle 5, 10, 25 and 50 µM, respectively). Together with the treatment with the anabolic steroids, 2% horse serum was added to the culture for the induction of differentiation of muscle cells. (Only for Reference) |
| Synonyms | 癸酸诺龙, 19-Nortestosterone decanoate |
| molecular weight | 428.65 |
| Molecular formula | C28H44O3 |
| CAS | 360-70-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.29 mg/mL (10 mM) |
| References | 1. Frankenfeld SP, et al. J Endocrinol. 2014, 220(2):143-153. 2. Beatriz Guimaraes Ribeiro, et al. Fisioter Pesq. 2014, 21(1):16-20. |