| Description | Naldemedine tosylate (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA) with high binding affinities (K_i = 0.34, 0.43, 0.94 nM) and potent antagonist activities (IC_50 = 25.57, 7.09, 16.1 nM) towards human recombinant μ-, δ-, and κ-opioid receptors, respectively. It is utilized in research on opioid-induced constipation (OIC). Additionally, Naldemedine tosylate is anticipated to interact with the 3CL proenzyme encoded by the SARS-CoV-2 genome. |
| Synonyms | S-297995 tosylate |
| molecular weight | 742.84 |
| Molecular formula | C39H42N4O9S |
| CAS | 1345728-04-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |