| Description | NAAD sodium salt (NAAD Na salt) is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate. |
| In vitro | NAAD sodium salt 在NAD+从色氨酸和NA2的生物合成过程中产生，在外周血单核细胞中的含量从不到20 nM升高到高达0.91 μM[3]。 |
| In vivo | 在小鼠体内，经过尼克酸（500mg/kg；腹腔注射）的给药后，可在肾脏、卵巢、肺、心脏和大脑观察到NAAD钠盐的存在；而当给予放射性尼克酰胺（500mg/kg；腹腔注射）后，NAAD sodium salt仅在小鼠肝脏中被检测到[3]。 |
| Synonyms | NAAD钠盐, NAAD Na salt, Deamido Nad Sodium Salt, NAAD Na, NaAD |
| molecular weight | 686.4 |
| Molecular formula | C21H25N6NaO15P2 |
| CAS | 104809-30-5 |
| Storage | store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29. 2. Patel S, et al. Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. Biochem J. 2000 Dec 15;352 Pt 3:725-9. 3. Samuel A J Trammell, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct 10;7:12948. 4. Ralf Jauch, et al. Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements. J Biol Chem. 2005 Apr 15;280(15):15131-40. |