| Description | N,N'-Diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits. N,N'-diacetyl-L-cystine is also an effective and orally active modulator of contact sensitivity/delayed-type hypersensitivity reactions in rodents. |
| In vivo | N,N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; p.o.; 每日; 12周; WHHL兔)治疗可以使胸主动脉动脉硬化减少50%，但对血浆脂质水平没有影响[1]。 |
| Synonyms | (Ac-Cys-OH)2, DiNAC |
| molecular weight | 324.37 |
| Molecular formula | C10H16N2O6S2 |
| CAS | 5545-17-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 15 mg/mL (46.24 mM), Sonication is recommended. |
| References | 1. Wågberg M, et al. N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. J Pharmacol Exp Ther. 2001 Oct;299(1):76-82. 2. Särnstrand B, et al. N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. J Pharmacol Exp Ther. 1999 Mar;288(3):1174-84. |