| Description | N-Methylquipazine is an agonist of 5-HT3. It has almost the same affinity for 5-HT3 sites as quipazine. |
| Synonyms | NMethylquipazine, J366.838J, N-Methylquipazine;NMethylquipazine, N-Methylquipazine |
| molecular weight | 227.3 |
| Molecular formula | C14H17N3 |
| CAS | 28614-26-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cappelli A, Giuliani G, Gallelli A, Valenti S, Anzini M, Mennuni L, Makovec F, Cupello A, Vomero S. Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor. Bioorg Med Chem. 2005 May 16;13(10):3455-60. PubMed PMID: 15848758. 2. Morreale A, Gálvez-Ruano E, Iriepa-Canalda I, Boyd DB. Arylpiperazines with serotonin-3 antagonist activity: a comparative molecular field analysis. J Med Chem. 1998 Jun 4;41(12):2029-39. PubMed PMID: 9622544. 3. Thorell JO, Stone-Elander S, Eriksson L, Ingvar M. N-methylquipazine: carbon-11 labelling of the 5-HT3 agonist and in vivo evaluation of its biodistribution using PET. Nucl Med Biol. 1997 Jul;24(5):405-12. PubMed PMID: 9290075. 4. Kurata K, Ashby CR Jr, Oberlender R, Tanii Y, Kurachi M, Rini NJ, Strecker RE. The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study. Synapse. 1996 Dec;24(4):313-21. PubMed PMID: 10638822. |