| Description | N-Desmethyl Loperamide is the major metabolite of loperamide. It is also used as the precusor for radiolabelled loperamide. |
| Synonyms | dLop, R20905, R-20905, R 20905 |
| molecular weight | 463.01 |
| Molecular formula | C28H31ClN2O2 |
| CAS | 66164-07-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Vaz RJ, Kang J, Luo Y, Rampe D. Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K(+) channel. Bioorg Med Chem Lett. 2017 Dec 15. pii: S0960-894X(17)31181-2. doi: 10.1016/j.bmcl.2017.12.020. [Epub ahead of print] PubMed PMID: 29274816. 2. Bhatti Z, Norsworthy J, Szombathy T. Loperamide metabolite-induced cardiomyopathy and QTc prolongation. Clin Toxicol (Phila). 2017 Aug;55(7):659-661. doi: 10.1080/15563650.2017.1304555. Epub 2017 Mar 28. PubMed PMID: 28349724. 3. Damont A, Goutal S, Auvity S, Valette H, Kuhnast B, Saba W, Tournier N. Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: A [(11)C]-N-desmethyl-loperamide PET study in nonhuman primates. Eur J Pharm Sci. 2016 Aug 25;91:98-104. doi: 10.1016/j.ejps.2016.06.005. Epub 2016 Jun 7. PubMed PMID: 27283486. 4. Wanek T, Römermann K, Mairinger S, Stanek J, Sauberer M, Filip T, Traxl A, Kuntner C, Pahnke J, Bauer F, Erker T, Löscher W, Müller M, Langer O. Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography. Mol Pharm. 2015 Sep 8;12(9):3214-25. doi: 10.1021/acs.molpharmaceut.5b00168. Epub 2015 Aug 3. PubMed PMID: 26202880; PubMed Central PMCID: PMC4566129. |