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N-(Azido-PEG3)-N-Boc-PEG4-acid

CAS No.: 2112731-95-8

N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker featuring a terminal azide group, primarily employed in PROT
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Description N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker featuring a terminal azide group, primarily employed in PROTAC synthesis[1].
In vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
molecular weight 566.64
Molecular formula C24H46N4O11
CAS 2112731-95-8
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Kanazaki K, et al. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23.