N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.
In vivo	N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea 在最初的测试中展现了抗癫痫活性，剂量为30 mg/kg，直至300 mg/kg都未见共济失调的迹象。剂量为30 mg/kg的活性在给药后4小时仍然存在。该化合物对最大电休克诱导的癫痫有效，但不能保护小鼠免受戊四氮所致的阵挛性癫痫。整体药理学特性表明，该化合物在治疗广泛性强直-阵挛性及部分性癫痫方面可能具有治疗价值[1]。
molecular weight	261.71
Molecular formula	C13H12ClN3O
CAS	97627-24-2
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 120 mg/mL (458.52 mM), Sonication is recommended.
References	1. Pavia MR, et al. N-Phenyl-N'-pyridinylureas as Anticonvulsant Agents. J. Med. Chem. 1990,33, 854-861

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