| Description | Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects. |
| In vitro | 在小鼠体内,Myricitrin（10/30 mg/kg,i.p.）对阿扑吗啡诱导的刻板和攀登行为有阻断效应,并使后肢撤回时间增加. |
| In vivo | 在啮齿动物的化学和机械疼痛模型中,佛波酯可激活蛋白激酶Cα和PKCε,Myricitrin可阻断该作用从而产生明显的镇痛作用。Myricitrin产生镇痛作用是因为钙离子内流减少及电压和小电导钙门控K(+)通道的开放。Myricitrin还对p53基因的表达有抑制作用,使胱天蛋白酶-3和MAPK信号通路被激活,并改变抗凋亡和促凋亡基因表达的模式,故可使血管内皮细胞中H2O2诱导的细胞凋亡减少。 |
| Synonyms | 杨梅苷, Myricetrin, Myricitrine |
| molecular weight | 464.38 |
| Molecular formula | C21H20O12 |
| CAS | 17912-87-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 86 mg/mL (185.2 mM) Ethanol: 1 mg/mL (2.15 mM) |
| References | 1. Meotti FC, et al. J Pharmacol Exp Ther, 2006, 316(2), 789-796. 2. Meotti FC, et al. Eur J Pharmacol, 2007, 567(3), 198-205. 3. Sun GB, et al. Toxicol Appl Pharmacol, 2013, 271(1), 114-126. 4. Pereira M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2011, 35(7), 1636-1644. 5. Liu H, Ye F, Sun Q, et al. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro[J] . Medicinal Chemistry. 2021, 36(1): 497-503. |
| Citations | 1. Liu H, Ye F, Sun Q, et al. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry. 2021, 36(1): 497-503 |