| Description | Mycothiol is a glyco-inositol-cysteine. It also conjugates exogenous compounds for detoxication. It also is the microbe equivalent of glutathione in the eukaryote. |
| molecular weight | 486.49 |
| Molecular formula | C17H30N2O12S |
| CAS | 192126-76-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hugo M, Van Laer K, Reyes AM, Vertommen D, Messens J, Radi R, Trujillo M. Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis. J Biol Chem. 2014 Feb 21;289(8):5228-39. doi: 10.1074/jbc.M113.510248. Epub 2013 Dec 30. PubMed PMID: 24379404; PubMed Central PMCID: PMC3931079. 2. Riordan SW, Field JJ, Corkran HM, Dasyam N, Stocker BL, Timmer MS, Harvey JE, Teesdale-Spittle PH. Synthesis of mycothiol conjugate analogues and evaluation of their antimycobacterial activity. Bioorg Med Chem Lett. 2015;25(10):2152-5. doi: 10.1016/j.bmcl.2015.03.070. Epub 2015 Mar 31. PubMed PMID: 25881831. 3. Nilewar SS, Kathiravan MK. Mycothiol: a promising antitubercular target. Bioorg Chem. 2014 Feb;52:62-8. doi: 10.1016/j.bioorg.2013.11.004. Epub 2013 Nov 21. Review. PubMed PMID: 24368170. 4. Pedre B, Van Molle I, Villadangos AF, Wahni K, Vertommen D, Turell L, Erdogan H, Mateos LM, Messens J. The Corynebacterium glutamicum mycothiol peroxidase is a reactive oxygen species-scavenging enzyme that shows promiscuity in thiol redox control. Mol Microbiol. 2015 Jun;96(6):1176-91. doi: 10.1111/mmi.12998. Epub 2015 Apr 11. PubMed PMID: 25766783. |