| Description | Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+. |
| In vitro | Mycalolide-B belongs to macrolide antibiotics and consists of tris-oxazole with strong cytotoxic activity (IC 50 : 10-50 nM for growth of L1210 murine leukemia cells). Mycalolide-B, a toxin isolated from marine sponge, inhibits smooth muscle contractions without changing cytosolic Ca 2+ levels. Mycalolide-B also inhibits Ca 2+ -induced contraction in permeabilized smooth muscles. Mycalolide-B inhibits superprecipitation and Mg 2+ -ATPase activity stimulated by Ca 2+ without changing myosin light chain phosphorylation. Mycalolide-B inhibits ATP-induced contraction and Mg 2+ -ATPase activity in the absence of Ca 2+[1]. |
| molecular weight | 1027.175 |
| Molecular formula | C52H74N4O17 |
| CAS | 122752-21-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hori M, et al. Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge. FEBS Lett. 1993;322(2):151-154. |