| Description | Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects. |
| Synonyms | Edrul, Muzolimina, Muzoliminum |
| molecular weight | 272.13 |
| Molecular formula | C11H11Cl2N3O |
| CAS | 55294-15-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Grima M, Michel B, Barthelmebs M, Stephan D, Imbs JL. The effects of muzolimine and urine from muzolimine-treated rats on Na+K+Cl- cotransport in Madin-Darby canine kidney cells. Eur J Pharmacol. 1991 Sep 17;202(2):137-42. PubMed PMID: 1802742. 2. Pohlmann-Eden B, Berlit P, Maibach EA, Gretz N. Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases. Acta Neurol Scand. 1991 Jan;83(1):41-4. PubMed PMID: 1849334. 3. Sastry CS, Suryanarayana MV, Tipirneni AS, Prasad TN. Spectrophotometric determination of muzolimine. Talanta. 1988 Nov;35(11):914-6. PubMed PMID: 18964644. 4. Planelles G, Meilhac B, Anagnostopoulos T. Effects of muzolimine on the late distal tubule of necturus kidney. J Pharmacol Exp Ther. 1988 Sep;246(3):1152-7. PubMed PMID: 3418514. |