| Description | Mtb-IN-4 (compound 17h) is a non-toxic isoxazole that exhibits anti-Mycobacterium tuberculosis (Mtb) activity, with an IC50 value of 0.70 μM. It impedes Mtb respiration and biofilm formation within macrophages and augments the efficacy of the antibiotic isoniazid (INH) against INH-resistant Mtb mutants [1]. |
| In vitro | Mtb-IN-4能有效地恢复Mtb katG突变体对INH的敏感性[1]。同时，Mtb-IN-4在小鼠RAW 264.7巨噬细胞中抑制Mtb生长，其半抑制浓度（IC 50）为3.467 μM[1]。 |
| molecular weight | 430.48 |
| Molecular formula | C24H18N2O4S |
| CAS | 2306039-13-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |