| Description | Mt KARI-IN-4 (compound 5c) is a highly effective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), demonstrating a Ki value of 5.48 μM. Additionally, Mt KARI-IN-4 displays inhibitory properties against Mtb H37Rv, with a minimum inhibitory concentration (MIC) of 0.78 μM. Importantly, this compound exhibits low levels of cytotoxicity, as evident from its half-maximal inhibitory concentration (IC 50 ) value of over 72 μg/mL against human embryonic kidney cells (HEK) [1]. |
| molecular weight | 365.36 |
| Molecular formula | C13H8FN5O3S2 |
| CAS | 2413974-53-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |