| Description | MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM). |
| In vitro | MSC2360844在浓度依赖的方式中抑制B细胞增殖，IC50为48 nM。MSC2360844 阻断淋巴细胞中BCR和TCR介导的反应，抑制在人原代细胞中通过pDC激发的TLR诱导的IFNα[1]。 |
| In vivo | 在小鼠SLE模型中，MSC2360844减轻了疾病表现[1]。 |
| Target activity | PI3Kδ:145 nM |
| molecular weight | 526.58 |
| Molecular formula | C26H27FN4O5S |
| CAS | 1305267-37-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90 mg/mL (170.91 mM), Sonication is recommended. |
| References | 1. Haselmayer P, et al. Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies. Front Immunol. 2014 May 22;5:233. |