| Description | MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM. |
| Synonyms | MS-453, MS 453 |
| molecular weight | 385.46 |
| Molecular formula | C20H27N5O3 |
| CAS | 2059892-29-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase Kyle V. Butler, Anqi Ma, Wenyu Yu, Fengling Li, Wolfram Tempel, Nicolas Babault, Fabio Pittella-Silva, Jason Shao, Junyi Wang, Minkui Luo, Masoud Vedadi, Peter J. Brown, Cheryl H. Arrowsmith, and Jian Jin Publication Date (Web): November 2, 2016 (Article) doi: 10.1021/acs.jmedchem.6b01244 |