| Description | MRS1177 is an effective and selective antagonist of the human Adenosine A3 receptor (hA3AR) (Ki: 0.3 nM). |
| In vitro | The Ki value of MRS1177 with hA3AR is 0.3 nM [1][2]. |
| Target activity | A3AR (human):(ki)0.3 nM |
| molecular weight | 389.79 |
| Molecular formula | C20H12ClN5O2 |
| CAS | 183721-13-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Tafi A, et al. Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. 2. Cheong SL, et al. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2898-905. |