| Description | MPT0B002 is a microtubule inhibitor that acts by downregulating T315I mutant Bcr-Abl and inducing apoptosis of imatinib-resistant chronic myeloid leukemia cells. |
| Synonyms | MPT-0-B-002, MPT 0 B 002 |
| molecular weight | 325.36 |
| Molecular formula | C19H19NO4 |
| CAS | 946077-08-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Yeh YY, Liou JP, Lee YL, Lin JY, Huang HM. MPT0B002, a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells. Invest New Drugs. 2017 Aug;35(4):427-435. doi: 10.1007/s10637-017-0457-9. Epub 2017 Mar 27. PubMed PMID: 28349229. |