| Description | Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM ) |
| In vitro | Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase(IC50 and a Kd of 367 nM and 27 nM). Mps1-IN-1 also has high affinity for ALK, and LTK, with Kds of 21 and 39 nM, respectively[1]. |
| Target activity | FAK:440 nM (kd), CLK1:1900 nM (kd), TYK1/LTK:29 nM (kd), PYK2:280 nM (kd), TNK1:2600 nM (kd), ERK2:2900 nM (kd), ALK:21 nM (kd), INSR:470 nM (kd), IGF-1R:750 nM (kd), Mps1:27 nM (kd), GAK:1100 nM (kd), TNK2:3100 nM (kd), INSRR:1200 nM (kd) |
| molecular weight | 535.66 |
| Molecular formula | C28H33N5O4S |
| CAS | 1125593-20-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 39 mg/mL (72.81 mM) |
| References | 1. Kwiatkowski N, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6(5):359-68. |