| Description | Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity. |
| In vitro | 开发了一种改进的HPLC方法，用于同时定量12种笼形黄酮，包括三对对映体和四对反式-顺式异构体，即forbesione、isoMorellic acid、Morellic acid、R-30-hydroxygambogic acid、S-30-hydroxygambogic acid、isogambogenic acid、gambogenic acid、gambogellic acid、R-isogambogic acid、S-isogambogic acid、R-gambogic acid和S-gambogic acid。该方法经验证具有敏感性、精确性和准确性，检测限为0.03-0.08 microg/mL，整体日内和日间变异度小于7.9%，整体回收率超过93.2%。校准曲线的相关系数(r(2))均高于0.995。新建立的方法成功应用于揭示不同产地的gamboges中这些分析物的化学剖面和含量差异。 |
| molecular weight | 560.63 |
| Molecular formula | C33H36O8 |
| CAS | 5304-71-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (89.19 mM) |
| References | 1. Improved high-performance liquid chromatographic method for simultaneous determination of 12 cytotoxic caged xanthones in gamboges, a potential anticancer resin fromGarcinia hanburyi.Biomedical Chromatography, 2008, 22(6):637-644. |