| Description | MMV024101 is a PI4K inhibitor. MMV024101 exhibits submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent compound remaining after 30 min of incubation. |
| Synonyms | MMV-024101, TCMDC 134293, TCMDC134293, TCMDC-134293, MMV 024101 |
| molecular weight | 352.37 |
| Molecular formula | C16H12N6O2S |
| CAS | 1092565-44-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria Nishanth Kandepedu†, Diego Gonzàlez Cabrera†, Srinivas Eedubilli†, Dale Taylor‡, Christel Brunschwig‡, Liezl Gibhard‡, Mathew Njoroge‡, Nina Lawrence‡, Tanya Paquet†, Charles J. Eyermann†, Thomas Spangenberg§ , Gregory S. Basarab†, Leslie J. Street†, and Kelly Chibale*†∥ |