| Description | MMV009085 is a potent inhibitor of the Plasmodium falciparum hexose transporter (Pf HT1), with potential as an anti-malarial agent. It also inhibits the human glucose transporter, demonstrating high potency with an IC50 of 2.6 μM in glucose uptake assays and an EC50 of 1.23±0.04 μM against the 3D7 strain of the malaria parasite [1]. |
| In vitro | MMV009085 对 PfHT-1 转运活性的 IC50 为 212±39 μM，并且它对疟原虫菌株 3D7 与 Dd2 生长的 EC50 分别为 1.23±0.04 μM 和 0.720±0.05 μM。对 HEK293T 和 HepG2 细胞线的 CC50 值，分别为 2.46±0.03 μM 和 1.92±0.85 μM [1]。在游离态疟原虫的葡萄糖摄取实验中，MMV009085 的 IC50 为 2.6 μM；而它通过阻断 PfHT 作用，对体外恶性疟原虫 3D7 株的生长抑制 EC50 为 0.987 μM（PfHT 阻断 EC50 为 0.795 μM）[1]。 |
| molecular weight | 410.42 |
| Molecular formula | C22H22N2O6 |
| CAS | 298217-59-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |